Nowadays, we know that lysosomes contain hydrolases that are capable ... electron microscopes and discovered a wide variety of vesicles. Some of the vesicles contained engulfed cytoplasmic material.

storage vesicles, or the plasma membrane (Figure 2). Lysosomes break down macromolecules into their constituent parts, which are then recycled. These membrane-bound organelles contain a variety of ...

This "transmembrane" region is known to house a channel that helps membranous vesicles, such as lysosomes, regulate pH—a measure of acidity or alkalinity—by transporting pH-lowering protons ...

The proteins are clustered in one vesicle and then another vesicle and then finally handed off to the lysosome. We think NU-9 targets something in the early stage of that relay, but we don't know ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...