Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management. Proceedings of the National Academy of Sciences , 2017; 114 (43): 11488 DOI: 10 ...

Study: Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis. Image Credit: Kateryna Kon / Shutterstock.com. What ...

LDO effectively reprograms macrophage polarization, alleviates CCL2-mediated cytokine storms and acute lung injury, and significantly improves the survival rate in sepsis animal models (Fig. 1).

Sepsis is the leading cause of death in critically ill ... KW, Swanson, PE, et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002;168:2493-2500. Crossref.

Sepsis can also be triggered by viral infections and may be involved in severe cases of COVID-19. "The biggest problem with sepsis is that it happens so fast, and once it gets going there are no ...

More information: "Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity" Immunity (2021). DOI: 10. ...

Macrophages are among the first cells involved in the body’s response to any injury or infection. ... Sepsis can also be triggered by viral infections and may be involved in severe cases of COVID-19. ...

Sepsis is a life-threatening, heterogeneous disorder involving a dysregulated immune response to infection. ... Macrophage activation–like syndrome, a high-risk subtype, ...

It also suggests that turning up macrophage activity – or blocking this “tolerance” – could help treat sepsis. Predicting immune response The researchers next showed that when macrophages were exposed ...

Sepsis-induced immunosuppression impedes the ability of monocytes, a type of white blood cell, to develop into macrophages capable of removing threats to the immune system.