ATP-dependent DNA ligases are found in all eukaryotic species. Mammalian cells contain four DNA ligase isozymes. Amino acid-sequence comparisons suggest that a core catalytic domain common to all ...
the E3 SUMO ligases PIAS1 and PIAS4 have an important role in the mammalian DDR pathway The ubiquitylation of histones H2A and H2AX at sites of DNA damage, which mediates the recruitment of ...
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