Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the cell, powers ATP synthesis in mammalian mitochondria by using the reducing potential of NADH to drive ...

The mitochondrial Complex I plays a central role in cellular respiration and energy metabolism. The ~1 Megadalton L-shaped protein complex is the largest protein assembly of the respiratory chain and ...

Structure of mammalian protein complex of respiratory chain solved at atomic level. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2016 / 09 / 160906131616.htm ...

In eukaryotes, respiratory chain complexes (RCCs) on the mitochondrial inner membrane (MIM) are essential components in energy metabolism. It is now widely accepted that RCCs tend to assemble into ...