Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...

Engagement of a GPI-anchored protein creates signaling rafts from smaller, transient, lipid rafts: Although membrane domain/rafts are implicated in receptor-mediated signaling and protein trafficking, ...

Researchers were able to observe, at an atomic scale and in real time, how membrane lipids interact with G protein-coupled receptors (GPCRs) in their natural environment. These interactions reveal ...

Previously unknown access points in cell membrane proteins have been discovered, enabling laboratory-developed drugs to modify cell function. The discovery was made possible through computer ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

ERBB receptors are regulated by their own intrinsic properties as well as by external associated proteins. What is regulation, where does it occur on the receptor, and how do scientists study it?

A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has ...

Blocking Piezo2, a protein receptor that senses mechanical forces in tissues, may be a new way to slow IPF progression, per a ...

Researchers found a protein that's essential for an enterovirus to enter human cells. Although not the infamous example—that ...

This study employed high-throughput screening and animal models to identify FPR2, a G protein-coupled receptor (GPCR) expressed at the adipocyte plasma membrane, as a critical ceramide receptor. This ...