Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and ... controlling the release of caspase activators from mitochondria during apoptosis.

We wanted to determine what happens to the cell when the lysosomes are not functioning well or are overwhelmed, and if there was another pathway to temporarily deal with the damaged mitochondria. This ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

"We wanted to determine which pathways are important for maintaining proper mitochondrial function," said Emily M. Walker, Ph.D, a research assistant professor of internal medicine and first ...

"This finding highlights a previously unknown connection between mitochondrial activity, inflammation control and the signaling pathways that regulate it," Chandel said. Overall, the findings ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling ...

In collaboration with Dr. Marks, we proved that SAHA induces apoptosis through the mitochondria-mediated caspase activation pathway. However, when we completely blocked that pathway using multiple ...