Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and ... controlling the release of caspase activators from mitochondria during apoptosis.

We wanted to determine what happens to the cell when the lysosomes are not functioning well or are overwhelmed, and if there was another pathway to temporarily deal with the damaged mitochondria. This ...

Organellar stress that affects mitochondria and the endoplasmic ... it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

"We wanted to determine which pathways are important for maintaining proper mitochondrial function," said Emily M. Walker, Ph.D, a research assistant professor of internal medicine and first ...

Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling ...