Liddle syndrome is an autosomal dominant disorder ... Competing Interests: The authors declared no competing interests. Monogenic hypertension is caused by single gene mutations and accounts ...

What can Gregor Mendel’s pea plants tell us about human disease? Single gene disorders, like Huntington’s disease and cystic fibrosis, actually follow Mendelian inheritance patterns.

We believe, and have now demonstrated, that gene therapy is a rational approach for the treatment of rare monogenic diseases ... candidates for SMA, Rett syndrome, SOD1 amyotrophic lateral ...

Monogenic hypertension is caused by single gene mutations ... which suppresses plasma renin activity These disorders should be suspected in young patients with a familyhistory of hypertension ...