Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed single-cell atlas of ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and ...

"By gaining the mutations, both cell states can give rise to leukemia, but with distinct biological properties that respond ...

Researchers have developed a new gene expression atlas to map how abnormal differentiation of hematopoietic cells can lead to acute myeloid leukemia (AML).

In chronic lymphocytic leukemia (CLL), certain recurrent genetic alterations are known to influence disease progression and ...

Apr. 11, 2025 — A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy ... for two forms of leukemia that are driven by mutations that involve gene fusions.

The atlas has been used to identify cell states in acute myeloid leukemia (AML) and shed light on the heterogeneity seen in the disease. In AML, genetic mutations disrupt hematopoietic differentiation ...

Primary endpoint met in R/R mNPM1 AML patients in pivotal Phase 2 portion of the AUGMENT-101 trial – – Robust remission rates in heavily pre-treated R/R mNPM1 AML population with nearly 50% overall ...

The team also employed additional techniques, such as uridine supplementation, to establish stable cell lines with different mutation loads, even those that might typically have a growth disadvantage.

Researchers show that glycoRNAs, uncovered by the lab of Nobel Laureate, Carolyn Bertozzi, can be used to fight cancer.

The new test focuses on mutations in the NPM1 and FLT3 genes, which are among the most common causes of leukemia in younger ...