A commercial myositis panel is able to differentiate between DM and ASS by measuring anti-nuclear antibody (increased in DM vs ASS) and Sjögren’s antibody A (found more frequently in patients ...

Anti-HMGCR antibodies showed highest predictive value for a myositis diagnosis, followed by anti-MDA5, anti-Jo-1, and anti-TIF1-γ, an analysis of 1068 people with positive myositis antibodies showed.

Anti-U1-RNP Antibody: Found in 5-10% of myositis patients, particularly those with mixed connective tissue disease. It can indicate a more favourable prognosis. Clinical Relevance And Implications ...

For patients with inclusion body myositis (IBM), the anti-NT5C1A antibody is abnormally distributed in the muscle, according to Paik. “It localizes to areas of myonuclear degeneration,” she said.

Researchers Detail Case of Statin-Induced Necrotizing Myositis. ... Testing showed that a mitosis panel was negative and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody was positive.

Finally, looking at inclusion body myositis, Paik called attention to ABC008 (Abcuro), a “first-in-class, humanized monoclonal antibody that binds to KLRG1” to deplete certain T cells, Paik said.

Abcuro Initiates Registrational Phase 2/3 Study of ABC008 for the Treatment of Inclusion Body Myositis. ... ABC008 is a first-in-class anti-KLRG1 antibody capable of selectively depleting highly ...

“Abcuro intends to use this imaging strategy as it advances ABC008, an anti-KLRG1 antibody capable of selectively depleting a subpopulation of highly-cytotoxic CD8+ T cells present in muscle ...