Objective: To investigate the efficacy and tolerability of high-dose N-acetylcysteine (NAC) in the treatment of patients with exacerbations of chronic obstructive pulmonary disease (COPD).

Nebulization-face mask, mouth piece, tracheostomy: 1–10mL of 20% soln or 2–20mL of 10% soln every 2–6 hours; usual dose: 3–5mL of 20% soln or 6–10mL of 10% soln 3–4 times daily.

Common severe NAC-related toxicities included neutropenia, thrombocytopenia, infection, and anemia, with dose reductions in 55% of patients. For some patients with bladder cancer, neoadjuvant ...

L-methylfolate calcium (Metafolin) 6mg, Algae-S powder 90.314mg, methylcobalamin 2mg, N-acetylcysteine 600mg; caplets. Avoid if renal stones occur. Do not administer to critically ill patients.

The participating subjects were randomly assigned, using a randomisation list for six-patient blocks, to one of three treatment groups: (a) a 10-day course of once-daily treatment with NAC 1200 mg ...