This process is called non-allelic homologous recombination (NAHR; also known as ectopic HR), and is discussed below. Change in copy number involves change in the structure of the chromosomes such ...

Genome rearrangements that lead to human disorders are typically thought to be caused by mistakes that occur during recombination. A new study into the genetic basis of a CNS disorder has revealed ...

The non-homologous part of the DNA is un-opened (purple). Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. 2002. BRCA2 function in DNA binding and ...

Mutations in BRCA1 and BRCA2 genes render derived tumors selectively sensitive to agents that generate lesions requiring DNA repair by homologous recombination. FANCJ, also known as BACH1 or BRIP1 ...