More information: Thirupathi Nuligonda et al, An enantioselective and modular platform for C4ʹ-modified nucleoside analogue synthesis enabled by intramolecular trans-acetalizations, Nature ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Antiviral nucleoside analogues and prodrug strategies are crucial in the development of effective treatments for viral infections. Nucleoside analogues mimic the building blocks of DNA and RNA ...

This combination regimen, added to these patients receiving ongoing nucleoside analogue therapy, showed that a good amount of them achieved a functional cure. I will be going over this data below ...

It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate ... it is the first nucleotide analogue reverse-transcriptase ...

A number of nucleoside analogues which were expected to exhibit antibiotic activity were inactive because they are not substrates for the enzymes that phosphorylate nucleosides. Nucleotides themselves ...

Lactic acidosis is a rare but often fatal complication reported in some human immunodeficiency virus (HIV)-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors.