More information: Thirupathi Nuligonda et al, An enantioselective and modular platform for C4ʹ-modified nucleoside analogue synthesis enabled by intramolecular trans-acetalizations, Nature ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Antiviral nucleoside analogues and prodrug strategies are crucial in the development of effective treatments for viral infections. Nucleoside analogues mimic the building blocks of DNA and RNA ...

A number of nucleoside analogues which were expected to exhibit antibiotic activity were inactive because they are not substrates for the enzymes that phosphorylate nucleosides. Nucleotides themselves ...

Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...

Lactic acidosis is a rare but often fatal complication reported in some human immunodeficiency virus (HIV)-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors.

Scientists at The University of Manchester and AstraZeneca have developed a new biocatalytic pathway that uses enzymes to produce nucleoside analogues, which are vital components in many ...