Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase (IDH) 1 and 2 are found in a large subset of diffusely infiltrating gliomas and subsets of acute ...

Figure 6: Sequence alignment and mutagenesis analysis of isocitrate dehydrogenase. Lysine succinylation induces more substantial changes to a protein's chemical properties than do lysine ...

Effect of mutant isocitrate dehydrogenase on cellular function ... should be paid to identify these actionable alterations when present. The most appropriate sequence of therapy for a given patient ...

Chemotherapy-Phased Imatinib Pulses Improve Long-Term Outcome of Adult Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Northern Italy Leukemia Group Protocol 09/00 The ...