Researchers have developed an improved type of PROTAC that has enhanced intracellular accumulation and functions, not only as a degrader, but also as an inhibitor of the target protein.

The ProTac 2.0 Headlamp is 4.92 inches wide and 2.56 inches deep with a head diameter of 1.46 inches. It weighs 10.48 ounces with the included SL-B50 rechargeable battery.

The Phase I single ascending dose (SAD) and multiple ascending dose (MAD) trial (EUCT-2023-507910-28-00) found ARV-102, a proteolysis targeting chimaera (PROTAC) therapy, led to a drop in leucine ...

The PROTAC market is anticipated to expand considerably in the near future, driven by the rising number of PROTAC-based drugs undergoing clinical trials from multiple companies. At present, no ...

I tested the Streamlights PROTAC HL® 4 HIGH LUMEN TACTICAL LIGHT, a dual power hand torch that throws can throw a beam out to 346 meters. The PROTAC HL® 4 is 8.63 inches long and weighs 1.1 lbs.

This PROTAC vaccine technology could also be useful for generating live-attenuated vaccines against other types of pathogens." Prof. Si Longlong from the Shenzhen Institute of Advanced Technology ...

The PROTAC candidates “… demonstrate potent antiretroviral activity in HIV-infected primary cells, supporting further development for testing in the context of HIV-1 reservoir reduction in ...

Article reference: Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang, Chunquan Sheng, NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloi d-derived suppressor cell ...

Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader. By James Waldron Mar 11, 2025 10:06am. Pfizer Arvinas breast cancer PROTAC. Pfizer and ...

Once PROTAC binds to its target protein and the ubiquitin ligase, the ligase will attach ubiquitin groups to the surface of the target protein, which tags it for degradation by the proteasome inside ...