Biological scientists from the National University of Singapore (NUS) have uncovered how the dengue virus uses its envelope ...

Biological scientists have uncovered how the dengue virus uses its envelope protein to capture human plasmin from a blood meal to enhance the permeability of the mosquito midgut for infection.

"A safe and effective dengue virus vaccine is clearly the long-term solution, but more immediate strategies are urgently needed to combat the current dengue problem." There is reason to be ...

Dengue viral infections can result in a range of symptoms. Some people show no symptoms or just have mild signs of the disease, but others develop severe complications. How does the body respond ...

This review discusses the epidemiology, burden and pathogenesis of dengue, as well as the vaccine candidates currently in clinical development. There is, therefore, an urgent unmet need for a safe ...

Because the weakened virus does not replicate well ... doi:10.1172/JCI21512 Stephenson, J. R. Understanding dengue pathogenesis: Implications for vaccine design. Bulletin of the World Health ...

Mongkolsapaya et al. performed a detailed analysis of dengue virus-specific T-cell responses in Thai children with dengue. They observed that during acute infection, up to 7% ...

A clinical trial supported by the National Institutes of Health (NIH) is testing an experimental treatment designed to help ...

If much more common viruses like dengue virus also target ANKLE2 ... “Thus, ZIKV’s unique pathogenesis derived from the NS4A-ANKLE2 interactions is from being in the wrong place at the ...

Researchers have uncovered how the dengue virus uses its envelope protein to hijack human plasmin to enhance transmission.