Here we show that attenuation of Wnt9b signaling during kidney morphogenesis affects the planar cell polarity of the epithelium and leads to tubules with significantly increased diameter.

The planar cell polarity (PCP) cascade is a conserved signaling pathway that governs the polarization of cells within the plane of a cell sheet. In vertebrates, PCP signals control cell polarity ...

This is called planar cell polarity (PCP ... focused on the fact that the Wnt5a signaling pathway controls the front-rear polarity (i.e., the cell shape during movement) of cells derived from ...

The process by which cells orient themselves correctly within the plane of an epithelial tissue is known as planar polarity. The molecular mechanism of planar polarity is understood best in fruit ...

and their colleagues provide promising new evidence Oct. 6 in the journal Science Advances that the "planar cell polarity," or PCP, a powerful signaling pathway that systematically polarizes cells ...