Little is known about the function of these metabolic products. However, some of them, produced by the so-called polyketide synthases, are known to be ecologically and pharmaceutically important ...

The dependence of polyketide synthase and terpene cyclase mechanistic adaptation on the chemistry of their oligomeric substrates illuminates a convergent evolutionary strategy for shaping ...

Extensive strain screening has identified many useful polyketide derived compounds of both 'macrolide' and 'polyaromatic' type produced by bacteria. In order to understand the biosynthetic processes ...