Researchers reviewing nearly 300 top-tier ADHD drug trials found that half skipped the rigorous, expert-led evaluations ...

Recent epidemiological studies have increasingly used graphical tools for causal inference. 12 Directed acyclic graphs (DAGs) are valuable in visualizing relationships among variables and representing ...

Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, ... (indicated by the diamond and the dashed line in each graph).

Multiple randomized controlled trials have shown that mask-wearing effectively blunts the spread of other coronaviruses and influenza-like diseases. Sign up for PolitiFact texts ...

Randomized controlled trials are the worst way to answer the question. By Baruch Fischhoff, Martin Cetron, and Katelyn Jetelina May 2, 2023. Reprints. Mark Lennihan/AP.

Both randomized controlled trials and real-world evidence can help define a treatment’s absolute value and its value relative to alternative interventions, but they do so in different ways.

Let me be clear: I’m not opposed to COVID boosters. I’ve taken them all, on schedule. People should have access to vaccines and make decisions in consultation with their physicians. But we also owe ...

“While single-arm trials will continue to play an important role, the randomized clinical trial remains the preferred approach to support the approval of new drugs, when feasible.” Agrawal and ...

Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE) NRG/GU010 - ...

Source Reference: Pan F, et al "Metformin for knee osteoarthritis in patients with overweight or obesity: a randomized clinical trial" JAMA 2025; DOI: 10.1001/jama.2025.3471.

Clarifying Causal Effects of Interest and Underlying Assumptions in Randomized and Nonrandomized Clinical Trials in Oncology Using Directed Acyclic Graphs and Single-World Intervention Graphs. JCO ...