Rather than restricting you to a live distro or forcing you to set up multiple partitions on an SSD/HDD, SBCs like the ...

The Raspberry Pi in general ... that conforms to the footprint of the Pi Zero is a good start, and the larger concept of creating additional modules is a worthy entry to the Hackaday Prize.

Cerebro clusterboard supports up to four Raspberry Pi, NVIDIA Jetson, or Radxa CM5 compute modules (crowdfunding) ...