Management of advanced renal cell carcinoma remains a persistent ... VEGF microvessel density and carbonic anhydrase IX [CAIX]) may be used to offer prognostic information for RCC.

Concomitant oral carbonic anhydrase inhibitors or other topical ... May be potentiated by quinidine. May inhibit renal excretion of basic drugs and promote excretion of acidic drugs.

Risk factors for metformin-associated lactic acidosis include renal or hepatic impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), ≥65yrs of age ...

The effect on the distal tubule is not dependent on carbonic anhydrase or aldosterone’s inhibitory effect. The therapy is contraindicated in individuals with anuria or with a history of ...