The cell cycle has been the subject of intense investigation during two periods since Virchow's 1855 realization that cells only arise from pre-existing cells. At the turn of the century ...

The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell ...

In multicellular organisms, how do multiple cell types originate from one cell and one genome? A critical early cell fate decision is whether to develop as germline (reproductive) or soma ...