A man was shot at while driving on Interstate 64 in St. Louis County on Feb. 5. According to police, the man was shot at when ...

A significant winter storm approaching St. Louis is prompting school and business closures across the region for Wednesday.

These key moments suggest two primary locations: One as the family navigates the interstates near the heart of Downtown St. Louis and another often associated with East St. Louis, Illinois.

ST. LOUIS COUNTY, Mo. — Drivers who use northbound Interstate 270 in west St. Louis County can expect delays for two ...

St. Louis, and Kansas City, drivers are used to seeing highway signs that give real-time updates to road conditions. Drivers see fewer of them on the interstates in rural sections of Missouri.

Police said distracted driving led to the crash, which brought Interstate 44 to a standstill for nearly six hours Wednesday. The crash happened around 6:10 a.m. near the Vandeventer Avenue exit in ...

A man who admitted to throwing rocks at cars from an overpass onto Interstate 64 in St. Louis has been placed on probation.

ST . LOUIS COUNTY, Mo. – An Austin, TX man is dead and two others are seriously injured overnight Wednesday morning after a ...

Advertisement Article continues below this ad According to the Missouri Department of Transportation's (MoDOT) online traveler map, all interstates and highways in St. Louis are labeled as covered ...