the linear DNA gets converted to a circular molecule because the viral DNA has sticky—or cohesive—ends,” said Mertz. She hypothesized that this also happened with EcoRI-cut SV40. This turned out to be ...

When they act on a DNA molecule, restriction enzymes produce "blunt" ends when they cut in the middle of the recognition sequence, and they yield "sticky" ends when they cut at the recognition ...

That’s impressive, given that the DNA packed into each of our cells has six billion letters and is two metres long. What happens next can vary. The standard Cas9 protein cuts the DNA at the target.

is used to illustrate how many restriction enzymes make cuts yielding sticky end fragments. After two fragments with complementary sticky ends are joined, the DNA backbone may be covalently sealed ...