Figure 2: Structure of GCL monomer and details of ThDP binding site. All previously described structures of ThDP-dependent enzymes have within 3.5 Å of the thiazol ring at least one ionizable ...

In 1958, Columbia University chemist Ronald Breslow proposed that vitamin B1 performs key metabolic processes in the body by forming a molecular structure known as a carbene. The problem ...

Vitamin B1 or thiamin is essential for glucose metabolism and nerve, muscle, and heart function. People may need supplements if their diet does not provide enough B vitamins, during hemodialysis ...

But for decades, scientists have suspected that vitamin B1, also known as thiamine, may form a carbene-like structure in our cells to carry out vital reactions in the body. Now, for the first time ...