In its bitter, seven-year-old lawsuit against Promega Corp., the Roche Group has just been deprived of one of its patents covering Taq DNA polymerase, the enzyme crucial to automating PCR. The federal ...

The team focused on T7 DNA polymerase’s thioredoxin binding domain (TBD), which has a structure similar to that of most thermostable polymerases, including Taq. Thioredoxin, which is ubiquitous in ...