Based on Patrick DeWitt's novel, this movie revolves around the colorfully ... California by the notorious assassins Eli Sisters (John C. Reilly) and Charlie Sisters (Joaquin Phoenix).

The scene that best defines “The Sisters Brothers” takes place along a river bank in the remote, anarchic, gold-rush California of 1851, when the film is set. Eli Sisters (John C. Reilly), a ...

Bobby traveled for months with the film, including to China ... "Elyse and I had a talk,'' her brother recalled. "I told her, this is serious. People are giving us a lot of money to do this.