There are four classes of pattern-recognition receptors: toll-like receptors (TLRs), C-type lectin receptors (CLRs), nucleotide-binding oligomerization domain (NOD) leucine-rich-repeat containing ...

In certain cell types, DNA is sensed by the cytoplasmic DNA receptor DNA-dependent activator of interferon (IFN) regulatory factors (DAI) to trigger a TANK-binding kinase 1 (TBK1)-dependent type I ...

Mammalian cells express different classes of germline-encoded pattern recognition receptors that monitor the ... 65,66 and KU70 (also known as XRCC6; a DNA sensor that induces type ...

The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol. 2010;11(5):373-384. ... Sun L, et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that ...

Nucleic acid immunity involves a sophisticated set of mechanisms for identifying nucleic acids by immune receptors, playing a vital role in physiological ...

Second genetic sensor for DNA methylation discovered Date: August 27, 2024 Source: Rockefeller University Summary: CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency ...

Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans. Immunity , 2023; DOI: 10.1016/j.immuni.2023.01.027 Cite ...

UMass Chan investigators identify new pattern recognition system that monitors disease-causing bacteria in C. elegans A nuclear hormone receptor intercepts pathogen-derived signals of growth and ...