Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression.

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

2010;7(4):519-542. PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS. Defective parkin activity ...

Yulan Huang, Yuan Gao, Zhenghong Lin, Hongming Miao, Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression, Genes & Diseases, Volume 12 ...