Hyun remarks, "Inhibiting the activity of ubiquitin specific peptidase 14 (USP14), a component of the proteasome complex, with IU1 enhanced not only proteasome activity but also autophagy activity ...

Many researchers working in areas outside autophagy, such as signalling, membrane trafficking, and ubiquitin-related processes, as well as researchers interested in various aspects of physiology ...

Autophagy is responsible for degrading and ... These changes interact with other proteostasis systems, like the ubiquitin-proteasome pathway, amplifying vulnerabilities to neurodegenerative ...

Hyun remarks: "Inhibiting the activity of ubiquitin specific peptidase 14 (USP14), a component of the proteasome complex, with IU1 enhanced not only proteasome activity but also autophagy activity ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...