Both deubiquitinases have an S2 catalytic domain in addition to the usual S1 ... They suggest that failing to remove ubiquitin from these proteins is linked to the disease. "Our findings not ...

these findings show an unanticipated level of regulation in the ubiquitin-conjugation cascade. E1 enzymes are characterized by an adenylation domain that is composed of two ThiF-homology motifs ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...