Ubiquitin ligases are enzymes involved in the ligation step of ubiquitylation. Ubiquitin ligases bind the substrate protein and catalyse the transfer of ubiquitin from the cysteine of ubiquitin ...

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, ...

Crowning the assembly, two PINK1 kinase domains lock together in a ... This, in turn, recruits the ubiquitin-ligase Parkin. PINK1 then sticks Parkin with phosphate groups, activating its ligase ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Ubiquitin is a small, covalent modifier that forms a poly-ubiquitin chain on protein, which becomes a degradation signal attacked by the 26S proteasome 11,12,13. The poly-ubiquitin chain is ...