The sequence context of UBDs and the conformational ... are modified following various cellular stimuli) to effector proteins (ubiquitin receptors containing one or more UBDs) have been elucidated ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through ... determinants for recognition of consensus SUMO modification sequences found within SUMO conjugated proteins.

Ubiquitin is a 76-amino-acid protein that is chemically unreactive ... molecular analysis using publicly available EST (expressed sequence tag) databases—gives the reader a real sense of ...

While its sequence made it part of a deubiquitinase ... They suggest that failing to remove ubiquitin from these proteins is linked to the disease. "Our findings not only add two additional ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Scientists at St. Jude Children's Research Hospital used fluorescent imaging techniques to track the sequence ... ubiquitin ligase, Siah2. Ubiquitin ligases facilitate the recycling of defunct ...