Second, it established the value or weight of each piece of evidence and how to combine them to reach one of five classification tiers: pathogenic, likely pathogenic, variant of uncertain significance ...

Alzforum webpages for each DIAN-TU-eligible variant now state “DIAN-TU eligibility: Yes” near the top of the page and an explanation under the Pathogenicity section (see, for example, PSEN1 M146V ).