We hypothesized that assessment of defects in high-molecular-weight (HMW) multimers of von Willebrand factor or point-of-care assessment of hemostasis could be used to monitor aortic regurgitation ...

Von Willebrand factor (VWF) is a protein crucial to the ... Circulating VWF is cleared rapidly from your bloodstream, with a half-life of about 16 hours, but this clearance rate is also highly ...

However, both patients had a severe deficiency of high-molecular-weight multimers of von Willebrand factor (less than 2 percent of the total multimers; normal range, 17 to 27 percent ...

In the study by Uriel et al, high-molecular-weight von Willebrand factor multimers were found to be reduced in all 31 HeartMate II patients in whom they were measured, and 18 of these 31 patients ...

The condition known as von Willebrand disease (vWD) is the result of a reduction in the plasma levels of, or the production of a defective form of, the coagulation factor known as von Willebrand ...

This genetic disorder causes alterations or deficits in von Willebrand factor (VWF), resulting in ... and the treatment showed a mean half-life of 21.9 hours (± 8.36). 1,2 No thrombotic events ...

The disease is caused by quantitative or qualitative deficiency of the von Willebrand factor (VWF) and is classified as type ... Although 1 ml of normal plasma contains 1 µg of VWFpp with a half-life ...

J Blood Med. 2011; 2: 49–57 6. Reininger AJ. The function of ultra-large von Willebrand factor multimers in high shear flow controlled by ADAMTS13. Hamostaseologie. 2015 May 18;35(3) ...

In its response to this, the body releases von Willebrand factor into the blood ... where it secretes in the form of multimers. As soon as some damage to the vessel occurs, then in order to ...

To help diagnose von Willebrand disease or other bleeding disorders, a doctor will request various blood tests. These tests will measure the presence and activity of certain substances in the blood.

Abstract: von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral ...