Von Willebrand factor (VWF) is a protein crucial to the ... clotting factors (factors I through XIII), which activate in a cascade critical to forming a blood clot. But the clotting cascade ...

In its response to this, the body releases von Willebrand factor into the blood ... then in order to eliminate it, a cascade of blood coagulability is launched in the body, in which VWF takes ...

To help diagnose von Willebrand disease or other ... VWF must also bind to blood clotting factor VIII to help stimulate the coagulation cascade, which activates proteins that enable clotting.

There are three subtypes: types 1 and 3 represent quantitative variants and type 2 is a group of four qualitative variants: (1) type 2A—characterized by defective von Willebrand factor-dependent ...