Ubiquitin ligases are enzymes involved in the ... by both the drug UM171 and cancer-associated mutations in the E3 ligase KBTBD4. Here, the authors use cryo-EM to demonstrate how these mutations ...

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, ...

The review delves into the E3 ubiquitin ligases, a specialized class of enzymes responsible for targeting specific proteins for degradation, and their interaction with CSCs. These ligases ...

The separation of chromatids is promoted by the anaphase-promoting complex (APC), an E3 ubiquitin ligase that, when active, causes the degradation of proteins that arrest the cell cycle.

Shanghai Helioson Pharmaceutical Co. Ltd. has synthesized molecular glue degraders comprising an E3 ubiquitin ligase coupled to a eukaryotic peptide chain release factor GTP-binding subunit ERF3A ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating ...

Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...

These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...

Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. My research interests ...