A new study led by UCLA investigators suggests that chronic stress and an unhealthy diet may work together to fuel the early ...

have discovered that protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin, dephosphorylation enzymes, promote sleep in mammals. The study is published in ...

Protein kinases such as PKA and PKC catalyze the transfer of phosphate groups from ATP molecules to protein molecules. Within proteins, the amino acids serine, threonine, and tyrosine are ...

A new study led by UCLA investigators suggests that chronic stress and an unhealthy diet may work together to fuel the early ...

At the molecular level, ADM triggers G s-coupled signaling that elevates cAMP and activates protein kinase A (PKA). PKA then phosphorylates PTP1B on serine 205, increasing the phosphatase's activity.