You could think of serine tRNA synthetase as a very smart friend that helps METTL6 figure out which tRNA to modify. The authors of the study believe this friendship is the first known example of a ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...

Without tRNA synthetases, there wouldn’t be a proper translation from the genetic code of DNA to messenger RNA to the amino-acid building blocks of proteins. tRNA synthetase enzymes may be a ...

Scientists have identified a new class of compounds capable of partially clearing the tropical parasite that causes Chagas ...

Amit Ghosh, Saraswathi Vishveshwara, A Study of Communication Pathways in methionyl-tRNA Synthetase by Molecular Dynamics Simulations and Structure Network Analysis, Proceedings of the National ...

Isoleucyl-tRNA synthetase 2 (IARS2) has previously been shown to be dysregulated in various cancers. This study showed that IARS2 expression was higher in PDAC tissues and cell lines.

Researchers from Atyr Pharma Inc. presented findings from the innovative tRNA synthetase platform, highlighting ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA ...

aTyr Pharma, Inc. Three out of four efzofitimod-treated diffuse SSc-ILD patients showed clinically important improvement based on the modified Rodnan Skin Score (mRSS) assessment at 12 weeks.

Researchers at Association Française Contre Les Myopathies, Consiglio Nazionale delle Ricerche, and Università degli Studi di Roma La Sapienza have disclosed peptidomimetics derived from leucyl-tRNA ...