Disinfectants induce oxidative damage in bacteria, but a single mutation triggers the expression of genes that help the ...
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Novel compound reduces Cryptosporidium parasite load by 99.8%In a study, "Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy," published in Science Translational Medicine ...
University of Washington has divulged compounds acting as methionyl-tRNA synthetase (bacterial) inhibitors reported to be useful for the treatment of bacterial and protozoal infections. BioWorld ...
During tRNA development, the researchers identified 12 highly active tRNA synthetase/tRNA pairs in Escherichia coli that can add canonical and noncanonical amino acids. Then, Badran’s team used ...
Blinded baseline demographics and disease characteristics for ongoing Phase 3 EFZO-FIT™ study of efzofitimod in pulmonary sarcoidosis; topline ...
In order to facilitate these applications, we have: 1) Developed new aminoacyl-tRNA synthetase/tRNA platforms that enable site-specific incorporation of previously inaccessible structural classes of ...
Oxford Drug Design’s advances are enabled by its dual-competence discovery platform. This platform integrates generative AI capabilities with tRNA synthetase expertise, including proprietary ...
Oxford Drug Design’s rapid advances have been enabled by its distinctive dual-competence discovery platform integrating pioneering generative AI capabilities with tRNA synthetase expertise, including ...
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