In a new study, researchers explain how tRNA-like components act as scaffolds for peptide bond formation between amino acid-bound "RNA minihelices," which are half tRNA-like molecules.

In a new study, researchers explain how tRNA-like components act as scaffolds for peptide bond formation between amino acid–bound “RNA minihelices,” which are half tRNA-like molecules ...

All living organisms encode the amino acid sequences of proteins as nucleotide sequences (genetic information) in their ...

The accuracy of aminoacyl-tRNA synthesis relies on the specificity of the synthetases for both amino acid and tRNA 1,7,8,9. Ribozyme synthetases should be capable of similar specificity.

The ribosome moves along the single strand mRNA, and when a complimentary codon sequence belonging to amino acid bearing tRNA bonds with the mRNA, the amino acid is added to the chain.

Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating and incurable diseases.

Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology ...

Apr. 21, 2022 — The process of 'translation' in protein synthesis involves formation of a peptide bond between two amino acids that are attached to two distinct transfer RNAs (tRNAs). For long ...

In previous attempts to expand the genetic code alphabet, researchers introduced into cells a tRNA that is linked to a non-canonical amino acid and recognizes a stop codon. 5 However, this strategy ...

As an example, the codon CGA instructs a tRNA to transfer the amino acid arginine to the ribosome. A common genetic mutation converts CGA to UGA, turning an arginine codon into a premature stop codon.

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to ...