"By doing so, APP-CTFs disrupt the delicate balance of calcium within lysosomes," explains Dr. Marine Bretou, first author of the study. "This disruption triggers a cascade of events. The ER can ...

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...