HER2 tumor marker tests are used to determine whether breast cancer is HER2 positive or negative. A person is a candidate for ...

Aldefluor-positive cells form tumors at all cell concentrations whereas the Aldefluor-negative cells fail to do so. (d) In HER2-amplified cell lines MDA-MB-453, HCC1954 and JIMT-1, only Aldefluor ...

HER2-negative breast cancers, on the other hand, have cells that contain little to no HER2 protein, so they tend to grow more slowly and have a better outlook than HER2-positive cancers, explains ...

June brought major breast cancer updates, and CURE is sharing the latest treatment combinations, biomarker-driven care and ...

Writing in the Journal of the American Chemical Society, Disney's group describes shifting three different cancer cell lines from HER2-negative status to HER2-positive status with the addition of ...

Tislelizumab-jsgr approved with chemotherapy for HER2-negative gastric or gastroesophageal junction adenocarcinoma, showing significant survival benefits. RATIONALE-305 study demonstrated a 20% ...

Results: The eight HER2 positive breast cancer cell lines tested, including trastuzumab and/or lapatinib resistant cells, responded to afatinib with IC 50 values ranging from 5 to 80 nM. The ...

Assessment of the HER2 status of CTCs within 7 days before a new line of anti-HER2 therapy in patients with histologically HER2-positive MBC revealed discordance of HER2 status between tissue and CTCs ...

HER2 expression is determined by two tests, one called an immunohistochemical (IHC) analysis that measures the amount of HER2 protein on cancer cells, and the other called in situ hybridization ...

PI3K Inhibitors have emerged as a popular treatment for hormone-receptor-positive breast cancers, improving progression-free survival rates for those with ER+ breast cancer.