Treatment of macrophages with a lower dose of rapamycin (10 μM) resulted in enhanced Ag85B presentation without mobilization of Mtb to the lysosomes , suggesting that Mtb-secreted cytosolic Ag85B ...

The method pioneered in this study, which combines three types of imaging (correlated light, electron and nano-scale ion microscopy), ... they infected human macrophages with Mtb, ...

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.