In March 2025, KRRO-110 received orphan drug designation from the U.S. Food and Drug Administration for the treatment of AATD. KRRO-110 is currently being evaluated in the Phase 1/2a REWRITE clinical ...

Three-in-one system integrates large fragment analytics, DNA size selection and fluorometric quantification for long-read ...

In April 2025 the Sixth and Final Subject of Cohort 1 was Safely Treated with the Low Dose of BB-301 in the Phase 1b/2a Clinical Treatment Study (NCT06185673)- -Independent Data Safety Monitoring Boar ...

-Following the Positive Data Safety Monitoring Board Recommendation, Enrollment of Cohort 2 is Expected to Begin in Q4 2025- ...

2.3 Relative synonymous codon usage analysis To evaluate synonymous codon usage independently of amino acid composition across various gene samples, the relative synonymous codon usage (RSCU) values ...

Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized and translated into more protein, while directing others to be degraded and ...

Codon bias, the usage patterns of synonymous codons for encoding a protein sequence as nucleotides, is a biological phenomenon that is not fully understood. Several methods exist to represent the ...

Codon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. Here we show that ...

Codon doesn't support Python module X or function Y. While Codon covers a sizeable subset of Python's standard library, it does not yet cover every function from every module. Note that missing ...