A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — ...

They are generated in living systems from acetyl-coA by the HMG-CoA reductase pathway. Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ ...

Through producing acetyl-CoA from acetate, ACSS2 epigenetically controls gene expression. However, whether and how ACSS2 regulates senescence remains unclear. Here, the authors link ACSS2 ...