Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis.

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions ...

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Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Specific ubiquitin–UBD interactions are crucial for the regulation of multiple ...

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"The new structures reveal differences in two thyroid hormone binding sites previously thought to be identical, and help explain why a drug binding to one site changes the ability of drugs to bind the ...

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Calcium is essential for neurotransmitter release. In the eIF4E mice, acetylcholine binding to dopamine axons was impaired, leading to less calcium influx. Increasing calcium restored dopamine ...

Department of Pharmaceutical Sciences, Medicinal Chemistry Section “Pietro Pratesi”, University of Milan, Via L. Mangiagalli 25, Milan 20133, Italy ...