for the development of patient-derived xenograft models that have advanced therapies targeting the HER/ERK and I (PI3K) signaling pathways in RAS/RAF-wild type and -mutant cancers; and for identifying ...

The AKT-PH-EGFP vector was co-expressed in MDA-MB-231 cells transfected ... VIPR2 and VIPR1 are also coupled to a Gαs protein pathway that signals the phosphorylation of ERK (15). In the current study ...

The Fellows of the AACR Academy have elected Elaine V. Fuchs, PhD, FAACR, as their next President. She will assume the ...

This was accompanied by an impairment of mitochondrial function with reduced expression of carnitine palmitoyltransferase I and an induction of acyl-coenzyme A oxidase-1 (ACOX1), oxidative stress and ...

We thank Professor John L. Rubenstein for his comments, suggestions, and edits. We are grateful to Professor Hua Han for sharing the Rbpj floxed mice, and Professor Jean M. Hebert for sharing ...

Background and aims: Ferroptosis, a novel concept of programmed cell death proposed in 2012, in kidney disease, has garnered significant attention based on evidence of abnormal iron deposition and ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

You can create a release to package software, along with release notes and links to binary files, for other people to use. Learn more about releases in our docs.

Docs and examples to StPageFlip: https://nodlik.github.io/StPageFlip/ Docs (generated by TypeDoc): https://nodlik.github.io/StPageFlip/docs/index.html ...