following the discovery of ALK translocations in a fraction of non-small-cell lung cancers and in other solid tumours. In cancers, all translocations involving ALK produce fusion proteins with ...
Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth. The enzyme, GUK1, supports metabolism in cancer cells to help tumors grow.
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Weakness in lung cancer's defenses found—an enzyme that boosts cancer cell metabolismWorking with mouse models and human cancer cells, the researchers identified a metabolic enzyme called GUK1 in lung cancers ...
Roche's Alecensa has been recommended for routine NHS use as an adjuvant treatment for ALK-positive non-small cell lung cancer (NSCLC), the first targeted therapy for this indication. Alecensa ...
An isogenic cell line was created to model cancer ... ALK. We employed the CRISPR/Cas9 genome editing platform for the generation of the desired targeted genomic rearrangement in the A549 lung ...
At CREST in 2007, Professor Mano discovered the EML4-ALK fusion gene; at Research Acceleration in 2012, he discovered the RET and ROSI fusion genes, which are all responsible for causing lung cancer.
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