Alosetron, a 5-HT 3 antagonist, slows colonic transit and increases intestinal fluid absorption [48] and has been tested in patients with diarrhea-predominant IBS ( Table 5). [49,50,51,52,53,54,55 ...

He was involved in the launch of Alosetron for the treatment of IBS, has progressed more than 30 clinical candidates, many of these into Phase II studies and 5 into Phase III studies. His ...

Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an ...

With chronic or severe diarrhea, the burning pain can last from several minutes to hours after a bowel movement depending on how severely the tissues are injured. If an anal fissure occurs, the pain ...

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and ...